Biography of Ernest Hemingway, Journalist and Writer

Biography of Ernest Hemingway, Journalist and Writer Ernest Hemingway (July 21, 1899–July 2, 1961) is considered one of the most influential writers of the 20th century. Best known for his novels and short stories, he was also an accomplished journalist and war correspondent.  Hemingways trademark prose style- simple and spare- influenced a generation of writers. Fast Facts: Ernest Hemingway Known For: Journalist and member of the Lost Generation group of writers who won the Pulitzer Prize and Nobel Prize in LiteratureBorn: July 21, 1899 in Oak Park, IllinoisParents: Grace Hall Hemingway and Clarence (Ed) Edmonds HemingwayDied: July 2, 1961 in Ketchum, IdahoEducation: Oak Park High SchoolPublished Works: The Sun Also Rises, A Farewell to Arms, Death in the Afternoon, For Whom the Bell Tolls, the Old Man and the Sea, A Moveable FeastSpouse(s):  Hadley Richardson (m. 1921–1927), Pauline Pfeiffer (1927–1939), Martha Gellhorn (1940–1945), Mary Welsh (1946–1961)Children: With Hadley Richardson: John Hadley Nicanor Hemingway (Jack 1923–2000); with Pauline Pfeiffer: Patrick (b. 1928), Gregory (Gig 1931–2001) Early Life Ernest Miller Hemingway was born on July 21, 1899 in Oak Park, Illinois, the second child born to Grace Hall Hemingway and Clarence (Ed) Edmonds Hemingway. Ed was a general medical practitioner and Grace a would-be opera singer turned music teacher. Hemingways parents reportedly had an unconventional arrangement, in which Grace, an ardent feminist, would agree to marry Ed only if he could assure her she would not be responsible for the housework or cooking. Ed acquiesced; in addition to his busy medical practice, he ran the household, managed the servants, and even cooked meals when the need arose. Ernest Hemingway grew up with four sisters; his much-longed-for brother did not arrive until Ernest was 15 years old. Young Ernest enjoyed family vacations at a cottage in northern Michigan where he developed a love of the outdoors and learned hunting and fishing from his father. His mother, who insisted that all of her children learn to play an instrument, instilled in him an appreciation of the arts. In high school, Hemingway co-edited the school newspaper and competed on the football and swim teams. Fond of impromptu boxing matches with his friends, Hemingway also played cello in the school orchestra. He graduated from Oak Park High School in 1917. World War I Hired by the Kansas City Star in 1917 as a reporter covering the police beat, Hemingway- obligated to adhere to the newspapers style guidelines- began to develop the succinct, simple style of writing that would become his trademark. That style was a dramatic departure from the ornate prose that dominated literature of the late 19th and early 20th centuries. After six months in Kansas City, Hemingway longed for adventure. Ineligible for military service due to poor eyesight, he volunteered in 1918 as an ambulance driver for the Red Cross in Europe. In July of that year, while on duty in Italy, Hemingway was severely injured by an exploding mortar shell. His legs were peppered by more than 200 shell fragments, a painful and debilitating injury that required several surgeries. As the first American to have survived being wounded in Italy in World War I, Hemingway was awarded a medal from the Italian government. While recovering from his wounds at a hospital in Milan, Hemingway met and fell in love with Agnes von Kurowsky, a nurse with the American Red Cross. He and Agnes made plans to marry once he had earned enough money. After the war ended in November 1918, Hemingway returned to the United States to look for a job, but the wedding was not to be. Hemingway received a letter from Agnes in March 1919, breaking off the relationship. Devastated, he became depressed and rarely left the house. Becoming a Writer Hemingway spent a year at his parents home, recovering from wounds both physical and emotional. In early 1920, mostly recovered and eager to be employed, Hemingway got a job in Toronto helping a woman care for her disabled son. There he met the features editor of the Toronto Star Weekly, which hired him as a feature writer. In fall of that year, he moved to Chicago and became a writer for  The Cooperative Commonwealth, a monthly magazine, while still working for the Star. Hemingway, however, longed to write fiction. He began submitting short stories to magazines, but they were repeatedly rejected. Soon, however, Hemingway had reason for hope. Through mutual friends, Hemingway met novelist Sherwood Anderson, who was impressed by Hemingways short stories and encouraged him to pursue a career in writing. Hemingway also met the woman who would become his first wife: Hadley Richardson. A native of St. Louis, Richardson had come to Chicago to visit friends after the death of her mother. She managed to support herself with a small trust fund left to her by her mother. The pair married in September 1921. Sherwood Anderson, just back from a trip to Europe, urged the newly married couple to move to Paris, where he believed a writers talent could flourish. He furnished the Hemingways with letters of introduction to American expatriate poet Ezra Pound and modernist writer Gertrude Stein. They set sail from New York in December 1921. Life in Paris The Hemingways found an inexpensive apartment in a working-class district in Paris. They lived on Hadleys inheritance and Hemingways income from the Toronto Star Weekly, which employed him as a foreign correspondent. Hemingway also rented out a small hotel room to use as his workplace. There, in a burst of productivity, Hemingway filled one notebook after another with stories, poems, and accounts of his childhood trips to Michigan. Hemingway finally garnered an invitation to the salon of Gertrude Stein, with whom he later developed a deep friendship. Steins home in Paris had become a meeting place for various artists and writers of the era, with Stein acting as a mentor to several prominent writers. Stein promoted the simplification of both prose and poetry as a backlash to the elaborate style of writing seen in past decades. Hemingway took her suggestions to heart and later credited Stein for having taught him valuable lessons that influenced his writing style. Hemingway and Stein belonged to the group of American expatriate writers in 1920s Paris who came to be known as the Lost Generation. These writers had become disillusioned with traditional American values following World War I; their work often reflected their sense of futility and despair. Other writers in this group included F. Scott Fitzgerald, Ezra Pound, T.S. Eliot, and John Dos Passos. In December 1922, Hemingway endured what might be considered a writers worst nightmare. His wife, traveling by train to meet him for a holiday, lost a valise filled with a large portion of his recent work, including carbon copies. The papers were never found. Getting Published In 1923, several of Hemingways poems and stories were accepted for publication in two American literary magazines, Poetry and The Little Review. In the summer of that year, Hemingways first book, Three Stories and Ten Poems, was published by an American-owned Paris publishing house. On a trip to Spain in the summer of 1923, Hemingway witnessed his first bullfight. He wrote of bullfighting in the Star, seeming to condemn the sport and romanticize it at the same time. On another excursion to Spain, Hemingway covered the traditional running of the bulls at Pamplona, during which young men- courting death or, at the very least, injury- ran through town pursued by a throng of angry bulls. The Hemingways returned to Toronto for the birth of their son. John Hadley Hemingway (nicknamed Bumby) was born October 10, 1923. They returned to Paris in January 1924, where Hemingway continued to work on a new collection of short stories, later published in the book In Our Time. Hemingway returned to Spain to work on his upcoming novel set in Spain: The Sun Also Rises. The book was published in 1926, to mostly good reviews. Yet Hemingways marriage was in turmoil. He had begun an affair in 1925 with American journalist Pauline Pfeiffer, who worked for the Paris Vogue. The Hemingways divorced in January 1927; Pfeiffer and Hemingway married in May of that year. Hadley later remarried and returned to Chicago with Bumby in 1934. Back to the U.S. In 1928, Hemingway and his second wife returned to the United States to live. In June 1928, Pauline gave birth to son Patrick in Kansas City. A second son, Gregory, would be born in 1931. The Hemingways rented a house in Key West, Florida, where Hemingway worked on his latest book, A Farewell to Arms, based upon his World War I experiences. In December 1928, Hemingway received shocking news- his father, despondent over mounting health and financial problems, had shot himself to death. Hemingway, whod had a strained relationship with his parents, reconciled with his mother after his fathers suicide and helped support her financially. In May 1928, Scribners Magazine published its first installment of A Farewell to Arms. It was well-received; however, the second and third installments, deemed profane and sexually explicit, were banned from newsstands in Boston. Such criticism only served to boost sales when the entire book was published in September 1929. The Spanish Civil War The early 1930s proved to be a productive (if not always successful) time for Hemingway. Fascinated by bullfighting, he traveled to Spain to do research for the non-fiction book, Death in the Afternoon. It was published in 1932 to generally poor reviews and was followed by several less-than-successful short story collections. Ever the adventurer, Hemingway traveled to Africa on a shooting safari in November 1933. Although the trip was somewhat disastrous- Hemingway clashed with his companions and later became ill with dysentery- it provided him with ample material for a short story, The Snows of Kilimanjaro, as well as a non-fiction book, Green Hills of Africa. While Hemingway was on a hunting and fishing trip in the United States in the summer of 1936, the Spanish Civil War began. A supporter of the loyalist (anti-Fascist) forces, Hemingway donated money for ambulances. He also signed on as a journalist to cover the conflict for a group of American newspapers and became involved in making a documentary. While in Spain, Hemingway began an affair with Martha Gellhorn, an American journalist and documentarian. Weary of her husbands adulterous ways, Pauline took her sons and left Key West in December 1939. Only months after she divorced Hemingway, he married Martha Gellhorn in November 1940. World War II Hemingway and Gellhorn rented a farmhouse in Cuba just outside of Havana, where both could work on their writing. Traveling between Cuba and Key West, Hemingway wrote one of his most popular novels: For Whom the Bell Tolls. A fictionalized account of the Spanish Civil War, the book was published in October 1940 and became a bestseller. Despite being named the winner of the Pulitzer Prize in 1941, the book did not win because the president of Columbia University (which bestowed the award) vetoed the decision. As Marthas reputation as a journalist grew, she earned assignments around the globe, leaving Hemingway resentful of her long absences. But soon, they would both be globetrotting. After the Japanese bombed Pearl Harbor in December 1941, both Hemingway and Gellhorn signed on as war correspondents. Hemingway was allowed on board a troop transport ship, from which he was able to watch the D-day invasion of Normandy in June 1944. The Pulitzer and Nobel Prizes While in London during the war, Hemingway began an affair with the woman who would become his fourth wife- journalist Mary Welsh. Gellhorn learned of the affair and divorced Hemingway in 1945. He and Welsh married in 1946. They alternated between homes in Cuba and Idaho. In January 1951, Hemingway began writing a book that would become one of his most celebrated works: The Old Man and the Sea. A bestseller, the novella also won Hemingway his long-awaited Pulitzer Prize in 1953. The Hemingways traveled extensively  but were often the victims of bad luck. They were involved in two plane crashes in Africa during one trip in 1953. Hemingway was severely injured, sustaining internal and head injuries as well as burns. Some newspapers erroneously reported that he had died in the second crash. In 1954, Hemingway was awarded the career-topping Nobel Prize for literature. Decline and Death In January 1959, the Hemingways moved from Cuba to Ketchum, Idaho. Hemingway, now nearly 60 years old, had suffered for several years with high blood pressure and the effects of years of heavy drinking. He had also become moody and depressed and appeared to be deteriorating mentally. In November 1960, Hemingway was admitted to the Mayo Clinic for treatment of his physical and mental symptoms. He received electroshock therapy for his depression and was sent home after a two-month stay. Hemingway became further depressed when he realized he was unable to write after the treatments. After three suicide attempts, Hemingway was readmitted to the Mayo Clinic and given more shock treatments. Although his wife protested, he convinced his doctors he was well enough to go home. Only days after being discharged from the hospital, Hemingway shot himself in the head in his Ketchum home early on the morning of July 2, 1961. He died instantly. Legacy A larger-than-life figure, Hemingway thrived on high adventure, from safaris and bullfights to wartime journalism and adulterous affairs, communicating that to his readers in an immediately recognizable spare, staccato format. Hemingway is among the most prominent and influential of the Lost Generation of expatriate writers who lived in Paris in the 1920s. Known affectionately as Papa Hemingway, he was awarded both the Pulitzer Prize and the Nobel Prize in literature, and several of his books were made into movies.   Sources Dearborn, Mary V. Ernest Hemingway: A Biography. New York, Alfred A. Knopf, 2017.Hemingway, Ernest. Moveable Feast: The Restored Edition. New York: Simon and Schuster, 2014.Henderson, Paul. Hemingways Boat: Everything He Loved in Life, and Lost, 1934–1961. New York, Alfred A. Knopf, 2011.Hutchisson, James M. Ernest Hemingway: A New Life. University Park: The Pennsylvania State University Press, 2016.

DID STEREOTYPING OF YOUNG MALE MUSLIMS INCREASE AFTER THE LONDON Research Paper

DID STEREOTYPING OF YOUNG MALE MUSLIMS INCREASE AFTER THE LONDON TRANSIT BOMBING ON 2005 - Research Paper Example Media played the major role to increase stereotyping in UK. The median focused on the radicalization of Islamic youths residing in UK by linking them to inadequate integration processes. The police departments were given direct orders to overcome the impacts from the incidents and punish the anti-social activists swiftly. Most of the Muslim male youths were harassed in UK after the incidents and the civil society of UK turned against the entire Muslim community. The number of reported incidents against the Muslim community and their worship places increased immediately after the bombing incidents of London. This research paper focuses on the impact of London bombings on racial profiling. On the 7th of July, a series of suicide bomb attacks were conducted in Central London. The attacks were majorly conducted to create massacre among the civilians using the public transport system. According to reports, it has been observed that four British Islamist men had detonated four bombs. Among the four bombs, three of them were detonated in the underground trains across the city. The fourth bomb was detonated on a double-decker bus. Almost one hour after the underground train attacks the fourth bomb was detonated on the number 30 bus (Goldstein 21). The attack occurred in Tavistock square, resulting in multiple injuries and death of innocent civilians. The incident occurred on a Tuesday, leaving 52 civilians dead and more than 700 injured. This incident has been regarded as the worst attacks, since 1988, i.e. the Lockerbie bombing. Before the London bombing incident, several other attacks took place in UK resulting in loss of many lives and properties. One of the most disastrous attacks occurred on 30 October, 1883. Two bombs exploded in the London underground railways in Paddington and Westminster Bridge station. In the year 1884, three

Business Informaton Managemnt BIM) Essay Example | Topics and Well Written Essays - 1750 words

Business Informaton Managemnt BIM) - Essay Example an easy to use communication channel to various individuals and corporations, information on almost every subject is readily available and it facilitates the conducting of various activities such as personal selling, account payments, advertising, publicity and even sales transactions among others With our focus on marketing, it must be borne in mind that the new information and communication technology has revolutionised the ways of marketing communication and doing business. The advent of the internet has brought about new features that make communication relatively easy and can reach a wide range of people located in diverse geographical areas. Digital communication via the use of the internet is very fast and effective. In terms of Marketing, Kotler (1998) calls this online marketing. Various companies have set up their online channels where marketing information about their products can be readily available from time to time. The internet is a medium that uses broadcasting and publishing with the aid of connectivity of computers that are online. Unlike other traditional forms of media, the use of the internet can facilitate a two way communication between the participants involved. In this case, both the marketer and the consumers have a direct link which makes it relati vely easier for the marketer to identify the needs and interests of the consumers. Thus, according to the marketing concept, marketing managers should try to identify the needs of their customers as well as satisfy them. In some instances, these customers are isolated and located further apart but their needs have to be satisfied which prompts the managers to undertake research in a bid to keep pace with the changes taking place in the market. Strydom, (2004 p86) defines marketing research as, â€Å"the systematic design, collection, interpretation and reporting of information used to help marketers solve specific problems to take advantage of marketing opportunities.† In undertaking this

Drug Mechanisms and Reactions

Drug Mechanisms and Reactions Phase 1: Drug Metabolism The whole range of biochemical processes that occur within an organism, Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The biochemical reactions are known as metabolic pathways and involve enzymes that transform one substance into another substance, either breaking down a substance or building a new chemical substance. The term is commonly used to refer specifically to the breakdown of food and its transformation into energy. The liver is the principal site of drug metabolism. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active sometimes even more than the parent compound. An inactive or weakly active substance that has an active metabolite is called a pro-drug, especially if designed to deliver the active moiety more effectively. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization, whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver. Drug metabolism rates vary among patients. Some patients metabolize a drug so rapidly that therapeutically effective blood and tissue concentrations are not reached, in others, metabolism may be so slow that usual doses have toxic effects. Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). For many drugs, metabolism occurs in two phases: Phase I reactions: Which involve formation of a new or modified functional group or cleavage, these reactions are nonsynthetic. Phase II reactions Which involve conjugation with an endogenous substance, these reactions are synthetic. Metabolites formed in synthetic reactions are more polar and more readily excreted by the kidneys (in urine) and the liver (in bile) than those formed in nonsynthetic reactions. Some drugs undergo only phase I or phase II reactions, thus, phase numbers reflect functional rather than sequential classification. Phase I Drug Metabolism Phase I metabolism includes oxidation, reduction, hydrolysis and hydration reactions, as well as other rarer miscellaneous reactions. Oxidations performed by the microsomal, mixed-function oxidase system (cytochrome P450-dependent) is considered separately because of its importance and the diversity of reactions performed by this enzyme system. Classification of Phase I Reactions: Oxidation Reduction Hydrolysis Hydration Dethioacetylation Isomerization Oxidations involving cytochrome P450 (the microsomal mixed-function oxidase) The mixed-function oxidase system found in microsomes (endoplasmic reticulum) of many cells (notably those of liver, kidney, lung and intestine) performs many different functionalisation reactions. CYP 450: The cytochrome P450(CYP) enzyme system consists of a superfamily of hemoproteins that catalyse the oxidative metabolism of a wide variety of exogenous chemicals including drugs, carcinogens, toxins and endogenous compounds such as steroids, fatty acids and prostaglandins. The CYP enzyme family plays an important role in phase-I metabolism of many drugs. The broad range of drugs that undergo CYP mediated oxidative biotransformation is responsible for the large number of clinically significant drug interactions during multiple drug therapy. All of these reactions require the presence of molecular oxygen and NADPH as well as the complete mixed-function oxidase system (cytochrome P450, NADPH-cytochrome P450 reductase and lipid). All reactions involve the initial insertion of a single oxygen atom into the drug molecule. A subsequent rearrangement and/or decomposition of this product may occur, leading to the final products formation. (i) Aromatic hydroxylation: This is a very common reaction for drugs and xenobiotics containing an aromatic ring. In this example the local anaesthetic and antidysrhythmic drug, lignocaine, is converted to its 3-hydroxy derivative. (ii) Aliphatic hydroxylation: Another very common reaction, e.g. pentobarbitone hydroxylated in the pentyl side chain. (iii) Epoxidation: Epoxides are normally unstable intermediates but may be stable enough to be isolated from polycyclic compounds (e.g. the precarcinogenic polycyclic hydrocarbons). Epoxides are substrates of epoxide hydrolase (discussed later), forming dihydrodiols, but they may also spontaneously decompose to form hydroxylated products or quinones. It has been suggested that epoxide formation is the first step in aromatic hydroxylation. (iv) Dealkylation: This reaction occurs very readily with drugs containing a secondary or tertiary amine, an alkoxy group or an alkyl substituted thiol. The alkyl group is lost as the corresponding aldehyde. The reactions are often referred to as N-, O- or S-dealkylations, depending on the type of atom the alkyl group is attached to. (v) Oxidative deamination: Amines containing the structure -CH(CH3)-NH2 are metabolised by the microsomal mixed-function oxidase system to release ammonium ions and leave the corresponding ketone. As with dealkylation, oxidative deamination involves an intermediate hydroxylation step with subsequent decomposition to yield the final products. The product of the oxidative deamination of EPI or NE is 3,4-didydroxyphenylclycoaldehyde (DOPGAL). DOPGAL is subject to reduction to the corresponding alcohol (3,4-dihydroxyphenylethylene glycol, DOPEG) or oxidation to the corresponding carboxylic acid (3,4-dihydroxymandelic acid, DOMA), the latter being the major pathway. (vi) N-oxidation: Hepatic microsomes in the presence of oxygen and NADPH can form N-oxides. These oxidation products may be formed by the mixedfunction oxidase system or by separate flavoprotein N-oxidases. The enzyme involved in N-oxidation depends on the substrate under study. Many different chemical groups can be N-oxidised including amines, amides, imines, hydrazines and heterocyclic compounds. (vii) S-oxidation: Phenothiazines can be converted to their S-oxides (sulfoxides (SÂ ¼O) and sulfones (Â ¼SÂ ¼O)) by the microsomal mixed-function oxidase system. (viii) Phosphothionate oxidation: The replacement of a phosphothionate sulfur atom with oxygen is a reaction common to the phosphothionate insecticides, e.g. parathion. The product paraoxon is a potent anticholinesterase and gives the potent insecticide action as well as the toxicity in humans. Oxidations not catalysed by cytochrome P450 (Non-Microsomal) A number of enzymes in the body not related to cytochrome P450 can oxidize drugs. (i) Alcohol Oxidation by Alcohol dehydrogenase: This enzyme catalyses the oxidation of many alcohols to the corresponding aldehyde and is localised in the soluble fraction of liver, kidney and lung cells. This enzyme uses NAD+ as co-factor and is a true dehydrogenase. (ii) Aldehyde oxidation: Aldehydes can be oxidised by a variety of enzymes involved in intermediary metabolism, e.g. aldehyde dehydrogenase, aldehyde oxidase and xanthine oxidase (the latter two being soluble metalloflavoproteins). (iii) Oxidation by Xanthine oxidase: This enzyme will metabolise xanthine-containing drugs, e.g. caffeine, theophylline and theobromine, and the purine analogues to the corresponding uric acid derivative. Metabolic Reduction (i) Azo- and nitro-reduction can be catalysed by cytochrome P450 (but can also be catalysed by NADPH-cytochrome P450 reductase). (ii) Ring cleavage: Epoxides can be converted back to the parent hydrocarbon, e.g. benzo(a)anthracene- 8,9-epoxide whereas some heterocyclic compounds can be ring cleaved by reduction. (iii) Reductive defluorination: Fluorocarbons of the halothane type can be defluorinated by liver microsomes in anaerobic conditions. Metabolic Hydrolysis Esters, amides, hydrazides and carbamates can readily be hydrolysed by various enzymes. (i) Ester hydrolysis: The hydrolysis of esters can take place in the plasma (nonspecific acetylcholinesterases, pseudocholinesterases and other esterases) or in the liver (specific esterases for particular groups of compounds). Procaine is metabolised by the plasma esterase, whereas pethidine (meperidine) is only metabolised by the liver esterase. (ii) Amide hydrolysis: Amides may be hydrolysed by the plasma esterases (which are so non-specific that they will also hydrolyse amides, although more slowly than the corresponding esters) but are more likely to be hydrolysed by the liver amidases. Ethylglycylxylidide, the N-deethylated phase 1 product of lignocaine, is hydrolysed by the liver microsomal fraction to yield xylidine and ethylglycine. (iii) Hydrazide and carbamate hydrolysis: Less common functional groups in drugs can also be hydrolysed, such as the hydrazide group in isoniazid or the carbamate group in the previously used hypnotic, hedonal. Factors Affecting Metabolism Many factors can affect liver metabolism, such as: In aging, the numbers of hepatocytes and enzyme activity declines. Diseases that reduce hepatic blood flow like heart failure or shock can also reduce the metabolic potential of the liver. Also the use of other drugs as well as dietary and environmental factors can influence liver metabolic function. Metabolism can also be altered due to a genetic deficiency of a particular enzyme. Differences in metabolism that result from functional genetic polymorphisms can be accommodated by knowing the frequency of different genotypes, and by modifying either the enzyme abundance (null alleles, for example, in the case of CYP2D6 poor metabolizers) or the intrinsic enzyme activity (for example, CYP2C9 variants). Data on developmental changes in the abundance and activity of different CYPs can also be incorporated into the models to predict hepatic clearance in neonates, infants and children. Conclusion Metabolism is the breakdown of Drugs inside the body, to disable their activity, forming inactive metabolites, however some drugs are either not affected by metabolism or activated by it, some even form toxic metabolites Examples: Imipiramine not affected by metabolism: Paracetamol produce Toxic Metabolite Metabolism occurs in two phases, Phase I Metabolism, and Phase II Metabolism. Phase I Metabolism converts the drug into metabolite by formation of a new functional group or modifying it, while phase II Metabolism or reactions involve conjugation with indigenous substance. Phase I Reactions Include: Oxidation, reduction, hydrolysis and hydration reactions, and other rare miscellaneous reactions. Oxidation can be divided into Microsomal or non Microsomal according to whether it involves mitochondrial CYP 450 enzymes. Oxidation involves: Microsomal Aromatic Hydroxylation, Aliphatic Hydroxylation, Epoxidation, Dealkylation, oxidative deamination, N- oxidation, S-oxidation and Phosphothionate oxidation. Non-Microsomal Alcohol Oxidation by Alcohol dehydrogenase, Aldehyde Oxidation and Oxidation by Xanthine oxidase. Reduction involves: Azo- and nitro-reduction, Ring cleavage, Reductive defluorination Hydrolysis involves: Ester hydrolysis, Amide hydrolysis, Hydrazide and carbamate hydrolysis

Analysis of Marrysong Dennis Scott Essay

Then Scott having to ‘chart’ – suggesting the creation of a map in order to discover his wife, this emphasises the exploration of this ‘new-found-land’. The poem suggests an unsure attitude, as we see in the first line, ‘year after year’ we don’t know whether this suggest a long, drawn out relationship that could become dull, or whether this means he is happy, and the year after year suggests commitment. Time takes a prominent role in the poem, with what is described as ‘year after year’ is then shortened to passing ‘seasons’ then shrunk still to an ‘hour’ until the shifting of moods becomes sudden, ‘suddenly she would change’. This suggests confusion within the relationship for Scott, as the changing of her attitudes becomes unexplainable and undetectable. This unpredictability leads us to the point of the heavy use of ‘enjambment’ in the first five lines, painting a vivid picture of uncertainty for Scott; conversely, as the poem progresses, we see a much more structured approach. On the contrary, the poem as a whole is generally lacking in structure. The constant use of caesurae, which breaks lines using pauses, denoted by commas and full stops. Also, the stutter of ‘[a]ll, all’’ disrupts the flow of the poem much like the punctuation mentioned. This disruptiveness also contributes to the uncertainty of Scott within the marriage. However, as we approach the concluding lines of the poem Scott evokes a discovery of certainty. He says ‘accepting her geography’ and stating that he ‘wondered’ which maybe suggests that he has no need to wander anymore. This final couplet also features a rhyming final two lines, which suggests stability and an atmosphere of certainty. The oxymoronic use of ‘jaunty helpless journey’ suggest that Scott is at his lover’s mercy; this is significant, as the whole poem conveys the idea that the woman dominates the relationship, and that Scott is exploring her and trying to figure her out. At the beginning of the poem we see that Scott says that she is under control by saying ‘under his eye’, this oxymoron features near to the end of the poem and, with numerous time frames being described in the lines between these two phrases, seems to suggest that after all this time he still has not been able to work her out or even gain control of their relationship. Conversely, this contrasts with the following two lines in which Scott is stated to have figured her out ‘find his way among the landscapes of her mind’. The fourth line, ‘in the walled anger of her quarried hurt’ takes a prominent role within the poem. The use of ‘walled’ and ‘quarried’ suggests an inescapable ‘territory’ into which Scott seems to be stuck. ‘Quarried’ also suggests that Scott is trying to unearth her personality, with ‘walled’ being the defensive behavior with which he does this. Love is a dangerous unreliable territory seems to be one of the main themes evoked by the poem. We see that Scott is continuously trying to gain power in the relationship. This seems to be unobtainable throughout the poem, however the title in itself reveals a childlike innocence about Scott; ‘Marrysong’ isn’t really a word, and sounds like a word a child would make up. It also evokes the bewildering nature of love and the complexity of marriage. Ovid: Ars Amatoria 1. 469-78 states that ‘dura tamen saxa’ (nonetheless, hard rocks) ‘molii cavantur aqua’ (are hollowed out by soft water). At one stage of the poem Scott states that one can see ‘cool water laughing where the day before there were stones in her voice’ – Scott maybe saying that the water hollowed out the rocks and overcame the rocks to make way for love. Furthermore, in relation to territory, Ovid states that ‘capta vides Pergama sero capita tamen’ (You can see that Troy was captured after a long delay, but she was captured in the end) relating to Scott claiming that his lover’s logic is like a territory needing to be explored, and the references of time relate to Ovid stating that Troy was captured ‘after a while’.

We Live For A Recreational Drug Culture - 1403 Words

We live in a recreational drug culture. According to Dr. Sam Richards, who is a well-known professor among Penn State students and academic society, it is widely accepted by society and by lawmakers that consumption of alcohol is reasonable for us and we should consume it. However, not many of us notice that fighting, vandalism, and rape occur because of that beverage (Richards). But what happens if everyone smokes marijuana instead of drinking alcohol? How did we come to the idea that marijuana is bad and alcohol is okay? Think about it. Growing up, everyone is told that, â€Å"Drugs are bad for you,† time and time again. Now as a kid you don’t really understand the reasoning behind it, but you listen to your authority figure regardless. People must first be aware of what Marijuana even is. The term Marijuana is originated from Mexican and Spanish words, mariguana and marihuana. Marijuana itself, comes from a widely cultivated Asian herb called hemp. The leaves and ot her parts of the hemp plant are smoked and provides a feeling of relaxation called â€Å"high†. Even though the substance does not have serious drawbacks, smoking it is still considered as a crime. The debate to legalize marijuana in the United States has been fought since it exist. There are many reasons for and against legalization, but the arguments for it outweigh the arguments against it. In this paper, I argue that marijuana should be legalized for three main reasons: Medical, economic and social benefits.Show MoreRelatedArgumentative Essay : The Legalization Of Marijuana1293 Words   |  6 PagesArgumentative Essay: The Legalization of Marijuana in the United States Should we legalize marijuana? That is an excellent question. First, we must explore the history of Cannabis. Cannabis was introduced to the United States in the 1600’s, first encouraged by the federal government for domestic hemp production, cannabis soon became a required crop for farmers to grow. 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Epic of Beowulf Essay - An Epic Poem - 1656 Words

Beowulf: An Epic Poem To qualify as an epic poem, Beowulf reflects the values of the culture in which it was created. The Anglo-Saxon culture and the poem share many of the same values. They shared a heroic ideal that included loyalty, strength, courage, courtesy, and generosity. Like all epic poems Beowulf is a long narrative work that tells the adventures of a great hero and also reflects the values of the society in which it was written. Both Beowulf and the Anglo-Saxons believed in those qualities as an individual. The strongest ties of loyalty in their society were to kin and lord. A kingdom was only as strong as its war-leader king. In order to have loyal men, the King needed to repay them. In other words the men†¦show more content†¦They burnt and destroyed the monuments of Roman occupation and let the roads and cities fall into utter disrepair. As Gildas, a British monks, phrases it, the red tongue of flame licked up the whole land form end to end, till it slaked its horrid thirst in the western ocean (Allen, 47). Those characteristics are also seen in the epic poem of Beowulf. It is a story of savage pirates, clad in shirts of ring-armoire, and greedy of gold and ale. The noblest leader is he who builds a great hall, throws up open for his people to carouse in, and liberally deals out beer, and bracelets, and money at the feast. Much of which they received from the king. When Beowulf first killed Grendel, there was a large feast in Hrothgar’s hall, Herot. There the queen se rved ale, and the king gave Beowulf and his men treasures. Fighting and drinking are the men’s’ two delights. The joy of battle is warm in their hearts. They are fearless and greedy and not ashamed of living by the strong hand alone. These men were always loyal to their king in the time of need because they were rewarded in the end (Allen, 16). Beowulf was a member of the Geat tribe who is described by the poet as greater/And stronger than anyone anywhere in this world (Beowulf,** 195-196).Beowulf is bringing fourteen of his strongest men across the sea to aid Hrothgar. Hrothgar did not ask for help from Beowulf or anyone else, but this warrior takes it upon himself toShow MoreRelated Epic of Beowulf Essay - Armor in the Epic Poem, Beowulf944 Words   |  4 Pagesthe poem Beowulf      Ã‚  Ã‚   Armor mentioned in the poem Beowulf include helmets and chain mail. There are an incredible number of references to these battle-apparel in the poem, making this topic of armor a very relevant one to consider.    â€Å"Helmets are the most dramatic and often quoted item of armor found in Beowulf,† says Catherine M. Hills in â€Å"Beowulf and Archaeology.† Indeed, examining the poem, one finds copious references to helmets in just the first 400 lines of the poem: Read MoreThe Pessimism of Beowulf in the Epic Poem, Beowulf Essay2837 Words   |  12 Pages  Ã‚  Ã‚   Anticipation of catastrophe, doom, gloom are present in Beowulf rom beginning to end, even in the better half of the poem, Part I. Perhaps this is part of what makes it an elegy – the repeated injection of sorrow and lamentation into every episode. In his essay, â€Å"The Pessimism of Many Germanic Stories,† A. Kent Hieatt says of the poem Beowulf: The ethical life of the poem, then, depends upon the propositions that evil. . . that is part of this life is too much for the preeminent manRead More The Epic Poem - Beowulf Essay2255 Words   |  10 Pages   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Beowulf is an epic poem. Why? Because (1) it is a long narrative work that relates the adventures of a great hero and (2) it reflects the values of the Anglo-Saxon society in which it was written prior to 1000AD. This Old English poem in unrhymed, four-beat alliterative style narrates, through the course of about 3200 verses, the bold killing of two monsters, Grendel and his Mother, and a fire-dragon, as well as numerous other brave deeds in lesser detail, by Beowulf, â€Å"the strongestRead MoreThe Epic Poem, Beowulf - A Jungian Reading of Beowulf Essay774 Words   |  4 PagesA Jungian Reading of Beowulf  Ã‚  Ã‚  Ã‚        Ã‚   The epic poem, Beowulf, depicts the battles and victories of the Anglo-Saxon warrior Beowulf, over man-eating monsters. The noble defender, Beowulf, constantly fought monsters and beasts to rid the land of evil. The most significant of these monsters, Grendel, represents Beowulfs shadow, the Jungian archetype explored in the essay collection, Meeting the Shadow.    The character Grendel portrays the fallen self, which will assert itself violentlyRead More The Theme of the Epic Poem, Beowulf Essay979 Words   |  4 PagesThe Theme of Beowulf      Ã‚  Ã‚  Ã‚   Interpretations of Beowulf vary. In this essay I hope to state clearly some of the popularly mentioned themes running through the poem.    â€Å"Many critics feel that the speech of Hrothgar between lines 1700 and 1784 encapsulates the moral of the poem†¦.’He does not know the worse – till inside him great arrogance grows and spreads’† (Shippey 38). Hrothgar’s ominous words do come back to haunt the hero more than once. Beowulf is a braggart; he is proud, andRead More The Epic Poem, Beowulf - Vengeance and Revenge in Beowulf Essay1328 Words   |  6 PagesVengeance and Revenge in Beowulf    The oldest of the great lengthy poems written in English and perhaps the lone survivor of a genre of Anglo-Saxon epics, Beowulf, was written by an unknown Christian author at a date that is only estimated.   Even so, it is a remarkable narrative story in which the poet reinvigorates the heroic language, style, and values of Germanic oral poetry.   He intertwines a number of themes including good and evil, youth and old age, paganism and Christianity and theRead MoreEssay on The Perfect Ruler in the Epic Poem, Beowulf2623 Words   |  11 Pages     Ã‚  Ã‚  Ã‚   The classic poem Beowulf presents the concept of the perfect king/leader/ruler. This is presented in two modes: the ideal Germanic king and the ideal Christian king. Literary scholar Levin L. Schucking in â€Å"Ideal of Kingship† states: â€Å"I have already tried to prove that the author of Beowulf designed it as a kind of Furstenspiegel (â€Å"mirror of a prince†) – perhaps for the young son of a prince, a thought with which Heusler later agreed† (36). So the author of Beowulf had in mind a humanRead MoreBeowulf: An Anglo-Saxon Epic Poem Essay1356 Words   |  6 Pages The epic poem Beowulf, is a work of fiction and was composed sometime between the middle of the seventh and the end of the tenth century of the first millennium, in the language today called Anglo- Saxon or Old English. This story is a heroic narrative, more than three thousand lines long, concerning the deeds of the Scandinavian prince, also called Beowulf, and it stands as one of the foundation works of poetry in English. Beowulf is obviously a creation of the poet, through partial comparisonsRead More Women in the Epic of Beowulf and in Other Anglo-Saxon Poems Essay1909 Words   |  8 PagesThe Women in Beowulf and in Other Anglo-Saxon Poems      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Are women in these poems active equals of the men? Or are they passive victims of the men? The roles of the women in Beowulf and other Anglo-Saxon poems are not always stereotyped ones of passive homemaker and childbearer and peaceweaver, but sometimes ones giving freedom of choice, range of activity, and room for personal growth and development. Beowulf makes reference to Ingeld and his wife and the coming Heathobard feud:Read MoreBeowulf : An Epic Poem Derived From Old World Storytelling Traditions1090 Words   |  5 PagesMs. Michelle Boykin EH 203 (Fall 2015) First Essay: Beowulf October 5, 2015 Beowulf: An Epic Poem Derived from Old World Storytelling Traditions The classic poem Beowulf recorded by a monk during eleventh century A.D., and of unknown authorship, is thought to have been passed down over time through oral traditions of storytelling, popular during that period in history. Most likely the listeners and retellers of these types of these stories would have been warriors themselves, much like